Translational Pharmacology

Pre-clinical studies using animal models play a very important role in the evaluation of efficacy and safety of new medical diagnostic devices before their use in human clinical studies. It provides an overview of the emerging role, results of pre-clinical studies and development, and evaluation of animal models for percutaneous cardiovascular intervention technologies for patients with symptomatic cardiovascular disease such as cardiac arrest or coronary heart disease. One prominent explanation is flawed preclinical research, in which the use and outcome of animal models is pivotal to bridge the translational gap to the clinic. Therefore, the selection of a validated and predictive animal model is essential to address the clinical question. In this review, the current challenges and limitations of animal models are discussed, with a focus on the fit-for-purpose validation.

Animal models are essential for translation of drug findings from bench to bedside. Hence, critical evaluation of the face and predictive validity of these models is important. Reversely, clinical bedside findings that were not predicted by animal testing should be back translated and used to refine the animal models. The translation of findings from bench to clinically relevant therapies is very complex. In fact, despite a full preclinical and clinical trial package, the large majority of drugs with initial phases based on translational-laboratory based discoveries actually fail to complete the development process. A lack of efficacy, side-effects, inappropriate doses, and pharmacokinetics are just a few of the various reasons for this failure.

  • Frontiers in Pharmacology
  • Quantitative system pharmacology
  • Advantages of using animal models
  • Clinical Toxicology
  • Ethanopharmacology
  • Translationability in animal models

Related Conference of Translational Pharmacology

Aug 21-22, 2017

World Medical Laboratory Congress & Expo

San Francisco, USA
September 21-22. 2017

3rd International Conference on Autism

Los Angeles, USA
October 18-20, 2017

10th World Congress on Biomarkers & Clinical Research

Baltimore, USA
November 13-15,2017

17th World Fitness Expo

(10 Plenary Forums - 1Event) Atlanta, USA
November 15-16, 2017

6th International Conference on Translational Medicine

San Antonio, Texas, USA
March 21-23, 2018

Annual Physicians Meeting 2018

Dubai, UAE

Translational Pharmacology Conference Speakers

Recommended Sessions

Related Journals

Are you interested in