Xiao Zhang
Guangdong Academy of Medical Sciences, China
Title: A serological biomarker in connective tissue disease-associated interstitial lung disease: KL-6
Biography
Biography: Xiao Zhang
Abstract
Objective To explore the possible diagnostic and imageology type values of the serum KL-6 level for InterstitialLung Disease (ILD) associated with Connective Tissue Diseases（CTD）.Methods 75 CTD patients divided into two groups , CTD with ILD group(44) and CTD without ILD group(31). Determination of serum KL-6 concentration in 75 CTD patients by Enzyme-Linked Immuno Sorbent Assay(ELISA). To compare the serum levels of KL-6 between the groups. Results The serum levels of KL-6 in the CTD with ILD were significantly higher than those CTD without ILD(P＜0.001).500U/ml as the normal ELISA cutoff level for serum KL-6.Sensitivity,specificity,positive and negative predictive values of serum KL-6 level for CTD-ILD were72.7%,87.1%,88.9%,69.2% ,respectively. There are no significant difference of serum KL-6 levels between the different imageology types：Usual Interstitial Pneumonia（UIP), Nonspecific Interstitial Pneumonia（NSIP）and indeterminate（P=0.84）. The serum levels of KL-6 in the group of wide lung lesions were significantly higher than those in the group of narrow lung lesions (P＜0.001).The mean serum KL-6 level of patients with active ILD was significantly higher than that of patients with inactive ILD (P＜0.001). Conclusion Serum KL-6 leves are a useful marker for diagnosis and evaluation of the extent of lung lesions and disease activity of CTD-ILD.