Rodrigo Dias Nunes
Universidade do Sul de Santa Catarina, Brazil
Title: Association between maternal and fetal factors and quality of cord blood as a source of stem cells
Biography
Biography: Rodrigo Dias Nunes
Abstract
Objectives: To comparatively analyze maternal and fetal factors and quality markers of bloodsamples in a public umbilical cord blood bank.Method: This is a cross-sectional descriptive study that revisited 458 records of donationsfrom September 2009 to March 2013 at the Hemocentro de Santa Catarina. The means ofmarkers were used to define cutoff points for the quality of cord blood.Results: Most donations came from women with ages between 18 and 29 years (62.8%),gestational age ≥ 40 weeks (55.2%), vaginal delivery (51.3%), primiparous (41.4%), and withmale newborns (54.4%) weighing between 3000 and 3499 g (41.8%). The volume of the dona-tions ranged from 71.6 to 275.2 mL, the total nucleated cell count ranged from 4.77 × 108to31.0 × 108cells and CD34+cells ranged from 0.05 to 1.23%. There were statistically significantdifferences in the volume with respect to gestation age > 38 weeks (p-value = 0.001), cesareansection (p-value < 0.001) and birth weight > 3500 g (p-value < 0.001). The total nucleated cellcount was positively affected by cesarean section (p-value = 0.022) and birth weight > 3500 g(p-value < 0.001). There was no statistically significant difference between the variables andthe percentage of CD34+cells.Conclusions: Delivery route and birth weight influence the volume of cord blood and the totalnucleated cell count. Gestational age influences only the volume of cord blood.