Yalin Song
West China School of Medicine, China
Title: Prognostic role of D-dimer in patients with lung cancer: A Meta-analysis
Biography
Biography: Yalin Song
Abstract
D-dimer detection in patients suffering from a variety of different types of cancer has become a hot point as an emerging and promising biomarker. In this study, therefore, we evaluated the prognostic role of D-dimer in lung cancer. MATERIALS AND METHODS: Initial literature was identified using PubMed, EMBASE and CNKI. The primary data was Hazard Ratio (HR) with 95% Confidence Interval (CI) of survival outcomes in candidate articles, including Overall Survival (OS) and Disease-Free Survival (DFS). RESULTS: Finally, 11 eligible studies were included in this meta-analysis, which were published between 1996 and 2013. The estimated pooled HR and 95%CI for OS of all studies was 2.06 (95%CI 1.64-2.58, p<0.00001) and the HR and 95%CI for DFS in one study was 3.38 (95% CI 1.17-9.75, p=0.002). The HRs and 95%CIs for OS in Asian and non-Asian patients were 2.48 (95%CI 1.60-3.84, p<0.0001) and 1.89 (95%CI 1.44-2.47, p<0.00001), respectively. When we further analyzed the data by various detecting methods, the pooled HR and 95%CI for OS was 3.22 (95%CI 1.99-5.21, p<0.00001) for ELISA, 1.52 (95%CI 1.25-1.86, p<0.0001) for Latex assay and 1.79 (95%CI 1.19-2.69, p=0.005) for immunoturbidimetry assay. We also did subgroup analysis according to the ratio of histological type and clinical stage. All above analysis had positive results. CONCLUSION: This meta-analysis showed that D-dimer had a fine predictive role in lung cancer patients, especially in Asian group. Also, it demonstrated that D-dimer had a stronger predictive value using the method ELISA.