Liwei Xie
University of Georgia, USA
Title: Transcriptomic analysis of rongchang pig brain and liver
Biography
Biography: Liwei Xie
Abstract
Pig is a one of widely used large animal models in biomedical and translational research as it shares similar characteristics in physiologic and anatomic levels, involving but not limited to cardiovascular and central nervous system. The fast development of Next Generation Sequencing (NGS) provides a useful tool to identify differentially regulated genes in large animals from the human disease-Ââ€relevant aspect. In current investigation, we sequenced RNAs from two major organs in pig, brain, the central nervous operator, and liver, the metabolic process center. From this study, we uncovered the major characteristics of the transcriptional profiles of neuron system-Ââ€related genes in two different organs. Furthermore, other than protein coding genes in two organ, we also identified ~2.5% noncoding genes, including microRNA, and long noncoding RNAs, which may paly an essential regulatory role in mRNA function. The results from current study provide a spectrum of gene expression profile information that can be further applied to the biomedical and clinical investigation of neurological and metabolic disorders related