Translational Medicine and Oncologists Meet

Sihem Bihorel (Ait-Oudhia) held the position of Research Assistant Professor at the State University of New York at Buffalo where she was also trained as a Post-doc and received her PhD. She utilizes quantitative systems pharmacology approaches to guide the development of new therapies and the identification of promising combination therapies as well as of novel biomarkers in oncology. She integrates quantitative systems pharmacology with PK/PD modeling and simulation to advance drug discovery and development, and leverage the understanding of drugs’ action which holds great promise to facilitate translational research. Her research is also focused on investigating how priming solid tumors with a pro-apoptotic agent then combining a subsequent large protein therapeutic and an antiagiogenic agent can defeat drug resistance and treatment failure in cancer and further enhance the efficacy of targeted anticancer agents, and translating these findings towards clinical settings.