Rohit Upadhyay
Weill Cornell Medical College, Qatar
Title: Role of SLMAP genetic variants in susceptibility of diabetes and diabetic retinopathy in Qatari population
Biography
Biography: Rohit Upadhyay
Abstract
Background : Overexpression of SLMAP gene has been associated with diabetes and endothelial dysfunction of macro- and micro-blood vessels. In this study, our primary objective is to explore the role of SLMAP gene polymorphisms in the susceptibility of type-2 diabetes (DM2) with or without Diabetic Retinopathy (DR) in the Qatari population. Methods: A total of 342 Qatari subjects (non-diabetic controls and DM2 patients with or without DR) were genotyped for SLMAP gene polymorphisms (rs17058639 C>T; rs1043045 C>T and rs1057719 A>G) using Taqman SNP genotyping assay. Results: SLMAP rs17058639 C>T polymorphism was associated with the presence of DR among Qataris with DM2. One-way ANOVA and multiple logistic regression analysis showed SLMAP SNP rs17058639 C>T as an independent risk factor for DR development. SLMAP rs17058639 C>T polymorphism also had predictive role for severity of DR. Haplotype Crs17058639Trs1043045Ars1057719 was associated with the increased risk for DR among Qataris with DM2. Conclusions : The data suggests the potential role of SLMAP SNPs as a risk factor for the susceptibility of DR among DM2 patients in Qatari population.