Translational Cardiology and Vascular Medicine

The goal of the Cardiac translational research is to accelerate translation of promising new fundamental research discoveries for the treatment of heart failure and arrhythmias through well-designed clinical trials that demonstrate efficacy and safety. Vascular medicine encompasses many different disease states. As the field of vascular medicine evolves, the scope of diseases being treated changes. Cardiac remodeling refers to the changes in size, shape, structure and physiology of the heart after injury to the myocardium. The injury is typically due to acute myocardial infarction. To characterize the increase in lipoprotein translation by hypothyroidism, adipocytes were prepared from control and hypothyroid rats. Whereas LPL synthesis was higher in hypothyroid adipocytes, with no change in mRNA levels, there was no increase in hormone-sensitive lipase (HSL) synthesis.

To determine whether a transacting translation regulatory factor was present, a cytoplasmic fraction was prepared from control and hypothyroid adipocytes, and added to an in vitro translation system containing the hLPL mRNA. Clinical outcomes with non-biologic therapy, given early in the course of the disease, are as good as with biologic therapies. Combinations of treatments are usually required to achieve rapid and sustained remission.

  • Stem cells in cardiac and vascular regeneration
  • New developments in cellular, viral, and non-biologic therapies
  • New concepts in cardiac remodelling
  • Metabolic and lipoprotein translation

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