Translational of Animal Models to the Clinic
Despite large investments in drug development, the general success rate of medicine during clinical development remains low. One prominent explanation is flawed preclinical research, during which the utilization and outcome of animal models are pivotal to bridge the translational gap to the clinic. Therefore, the choice of a validated and predictive animal model is important to deal with the clinical question. the present challenges and limitations of animal models are discussed, with attention on the fit-for-purpose validation.
- Alzheimer disease
- Neurodegeneration
- Stroke
- Schizophrenia
- Addiction
- Pain
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